Checkpoint Proteins Diagram

At the core of the checkpoint immuno-onco-therapy is the infiltrated T-lymphocytes expressing an array of checkpoint proteins on the cell surface for proximal interrogation of the tumor microenvironment. The temporal and kinetic engagement of one or more of these receptors with the respective ligand(s) lead to an overall activating or inhibitory state of these T cell and result in suppressing or facilitating the growth tumor cells, respectively.

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