CD30 is a surface marker for neoplastic cells of Hodgkin's lymphoma and shows sequence homology to members of the tumor necrosis factor receptor (TNFR) superfamily.
Interacting protein(s): CD-30
Related products: Hexa-Ligand
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Quick SpecAbs 0.1% (1 mg/ml)
|Synonym:||TNFSF8, CD153, CD30LG|
|Construction:||His-FLAG-h. CD30L (Q63-D234)|
|MW (calculated):||22,111 daltons|
|MW (SDS-PAGE):||25 Kd|
|Abs 0.1% (= 1 mg/ml):||1.048|
CD30 is a surface marker for neoplastic cells of Hodgkin's lymphoma and shows sequence homology to members of the tumor necrosis factor receptor (TNFR) superfamily. CD30L is a 239 amino acid type II membrane protein whose C-terminal domain shows significant homology to TNF alpha, TNF beta, and CD40L. CD30L’s receptor, CD30, is expressed by activated, but not by resting, T and B cells. CD30 is associated with anaplastic large cell lymphoma.
It is expressed in embryonic carcinoma but not in seminoma and is thus a useful marker in distinguishing between these germ cell tumors. CD30 is also expressed on classical Hodgkin Lymphoma cells. In addition, CD30 mediates positive signals for apoptosis, has been shown to limit the proliferative potential of auto-reactive CD8 effector T cells and protect the body against autoimmunity.
The recombinant CD30L enhances the proliferation of CD3-activated T cells yet induces differential responses, including cell death, in several CD30+ lymphoma-derived clones.
Amino Acid Sequence
1. CD30 antigen, a marker for Hodgkin's lymphoma, is a receptor whose ligand defines an emerging family of cytokines with homology to TNF. Smith C.A., Gruess H.-J., Davis T., Anderson D., Farrah T., Baker E., Sutherland G.R., Brannan C.I., Copeland N.G., Jenkins N.A., Grabstein K.H., Gliniak B., McAlister I.B., Fanslow W., Alderson M., Falk B., Gimpsel S., Gillis S. expand/collapse author list Armitage R.J. Cell 73:1349-1360 (1993)
2. Characterisation of the human CD30 ligand gene structure. Croager E.J., Abraham L.J. Biochim. Biophys. Acta 1353:231-235 (1997)