BAFF (B-cell activating factor) is expressed as a type II membrane protein on various cell types including monocytes, dendritic cells and bone marrow stromal cells and is a member of the tumor necrosis factor (TNF) ligand family.
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|Synonym:||CD257, TNFSF13B, BLYS, DTL, TALL-1, TALL1, THANK, TNFSF20, ZTNF4|
|Construction:||His-FLAG-Human BAFF (Q136-L285)|
|MW (calculated):||19,355 daltons|
|MW (SDS-PAGE):||20 Kd|
|Abs 0.1% (= 1 mg/ml):||0.829|
BAFF (B-cell activating factor) is expressed as a type II membrane protein on various cell types including monocytes, dendritic cells and bone marrow stromal cells and is a member of the tumor necrosis factor (TNF) ligand family. BAFF interacts with differing binding affinities to three receptors, BAFF-R (BR3), TACI (transmembrane activator and calcium modulator and cyclophilin ligand interactor), and BCMA (B-cell maturation antigen).
BAFF-R is involved in the survival of B cells during their development. The functional significance of BAFF’s interactions with the other two receptors are less clear. Unique within the TNF ligand family, BAFF is known for capable of forming the virion like 60-mer structures – in addition to forming the traditional homotrimeric structure.
BAFF is indispensable in normal B cell development as the examination of secondary lymphoid organs from BAFF-deficient mice revealed a complete loss of follicular and marginal zone B lymphocytes. In contrast, excessive level of BAFF causes abnormally high antibody production, results in systemic lupus erythmatosis, rheumatoid arthritis, and many other autoimmune diseases.
Amino Acid Sequence
1. Schneider P, MacKay F, Steiner V, Hofmann K, Bodmer JL, Holler N, Ambrose C, Lawton P, Bixler S, Acha-Orbea H, Valmori D, Romero P, Werner-Favre C, Zubler RH, Browning JL, Tschopp J. (1999) BAFF, a novel ligand of the tumor necrosis factor family, stimulates B cell growth. J Exp Med. 189:1747-1756.
2. Thompson JS, Bixler SA, Qian F, Vora K, Scott ML, Cachero TG, Hession C, Schneider P, Sizing ID, Mullen C, Strauch K, Zafari M, Benjamin CD, Tschopp J, Browning JL, Ambrose C (2001) BAFF-R, a newly identified TNF receptor that specifically interacts with BAFF. Science 293:2108-2111.
3. Schiemann B, Gommerman JL, Vora K, Cachero TG, Shulga-Morskaya S, Dobles M, Frew E, Scott ML (2001) An essential role for BAFF in the normal development of B cells through a BCMA-independent pathway. Science 293:2111-2114.