TACI (Fc-Fusion)

TACI (transmembrane activator and calcium modulator and cyclophilin ligand interactor), a type I membrane protein, is a member of the TNF receptor superfamily.

Interacting protein(s): BAFF (P7003M), APRIL (P7002F)
Related products: TNF-Receptor Superfamily

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Quick Specs

Description

TACI (transmembrane activator and calcium modulator and cyclophilin ligand interactor), a type I membrane protein, is a member of the TNF receptor superfamily. TACI interacts with two ligands, the BAFF (B cell activation factor) and APRIL (proliferation-inducing ligand). Engagement of TACI with its ligand(s) is thought to trigger inhibitory signal(s) as TACI-deficient mice develop fatal autoimmune glomerulonephritis, proteinurea, and elevated levels of circulating autoantibodies.

Treatment of B cells with TACI agonistic antibodies inhibits proliferation in vitro and activation of a chimeric receptor containing the TACI intracellular domain induces apoptosis. Interestingly, TACI mutations are associated with immunodeficiency in humans, as a significant proportion of CVID patients have TACI mutations. People with this condition produce abnormally low amounts of antibodies, which are needed for protection against infections.

In humans, the gene encoding this protein is located within the Smith-Magenis syndrome region on chromosome 17. Soluble TACI protein, particularly the dimeric protein fused with IgG Fc domain is a robust decoy for both BAFF and APRIL.

Amino Acid Sequence.

References

1. von Bülow, G U, Bram R J (1997). NF-AT activation induced by a CAML-interacting member of the tumor necrosis factor receptor superfamily. Science 278 : 138–41
2. Seshasayee D, Valdez P, Yan M, Dixit VM, Tumas D, Grewal IS. (2003) Loss of TACI causes fatal lymphoproliferation and autoimmunity, establishing TACI as an inhibitory BLyS receptor. Immunity 2003 18:279-88.
3. Freiberger T, Ravčuková B, Grodecká L, Pikulová Z, Stikarovská D, Pešák S, Kuklínek P, Jarkovský J, Salzer U, Litzman J. (2012) Sequence variants of the TNFRSF13B gene in Czech CVID and IgAD patients in the context of other populations. Hum Immunol. 73:1147-1154