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TNF-Receptor Superfamily

Protein Name Species Fusion Tag Catalog Code Interacting Protein(s)
BAFFR human Mouse IgG2a Fc P114F BAFF (P003M)
BAFFR human His-Flag P114M BAFF (P003M)
BAFFR human Mouse IgG2a aglyco-Fc P114G BAFF (P003M)
BCMA macaque Mouse IgG2a Fc P115F BAFF, APRIL
BCMA human Mouse IgG2a Fc P011F BAFF (P003M), APRIL (P002F)
BCMA human His-Flag P011M BAFF (P003M), APRIL (P002F)
BCMA human Mouse IgG2a aglyco-Fc P011G BAFF (P003M), APRIL (P002F)
CD27 human Mouse IgG2a Fc P082F CD27L (P004F)
CD40 human No Tag P015Xp CD40L (P005F), CD40L (P005H), CD40L (P005M), CD40L (P005Xp)
DcR3 human Mouse IgG2a Fc P073F TL1A-S (P028F), TL1A-L (P042F), FASL
DR3 human Mouse IgG2a Fc P065F TL1A-S (P028F), TL1A-L (P042F)
DR4 human Mouse IgG2a Fc P049F TRAIL (P008F)
DR5 human Mouse IgG2a Fc P053F TRAIL (P008F)
EDAR human Mouse IgG2a Fc P045F EDA (P030F)
FAS human Mouse IgG2a Fc P061F FASL
GITR human Mouse IgG2a Fc P035F GITRL
GITR human Mouse IgG2a aglyco-Fc P035G GITRL
HVEM human Mouse IgG2a Fc P076F LT-a (P006M), LIGHT, BTLA
HVEM human Mouse IgG2a aglyco-Fc P076G LT-a (P006M), LIGHT, BTLA
LTbR human Mouse IgG2a Fc P079F LT-α1β2, LIGHT
NGFR human Mouse IgG2a Fc P017F NGF, NTF-3, NTF-4, BDNF
OPG human Mouse IgG2a Fc P019F TRAIL (P008F), RANKL
OPG human His-Flag-Myc P019MT TRAIL (P008F), RANKL
OPG human Mouse IgG2a aglyco-Fc P019G TRAIL (P008F), RANKL
OX40 human Mouse IgG2a Fc P046F OX40L
OX40 human Mouse IgG2a aglyco-Fc P046G OX40L
RANK human Mouse IgG2a Fc P032F RANKL
TACI human Mouse IgG2a Fc P012F BAFF (P003M), APRIL (P002F)
TACI human Mouse IgG2a aglyco-Fc P012G BAFF (P003M), APRIL (P002F)
TNFR1 macaque Mouse IgG2a Fc P120F TNF, LT-a
TNFR1 human Mouse IgG2a Fc P020F TNF (P113MT), TNF (P113F), TNF (P113M), LT-a (P006M)
TNFR1 human Mouse IgG2a aglyco-Fc P020G TNF (P113MT), TNF (P113F), TNF (P113M), LT-a (P006M)
TNFR2 human Mouse IgG2a Fc P022F TNF (P113MT), TNF (P113F), TNF (P113M), LT-a (P006M)
TNFR2 human Mouse IgG2a aglyco-Fc P022G TNF (P113MT), TNF (P113F), TNF (P113M), LT-a (P006M)
TRAIL-R3 human Mouse IgG2a Fc P057F TRAIL (P008F)
TRAL-R4 human Mouse IgG2a Fc P059F TRAIL (P008F)

In human, 29 members of the TNF receptor (TNFR) family have been identified. Most of them are type I membrane proteins with a few exceptions. BCMA, BAFFR, TACI and XEDAR all lack the signal peptide and are classified as type III membrane proteins. Both OPG and DcR3 are soluble proteins and the TRAIL-R3 is tethered to membrane with a glycolipid. In addition, a number of TNFRs including CD27, CD30, CD40, TNFR1 and TNFR2 can be proteolytic processed into soluble receptors. FAS and 4-1BB also express as soluble form by alternatively slicing off the transmenbrane-encoding exon. Soluble receptors, each being able to interact with its ligand, are shown to modulate the activity of the respective membrane anchored receptor. Many TNF receptors interact with more than one ligand. These include both TNFR1 and TNFR2 interact with TNF-α and LT-α, both BCMA and TACI interact with BAFF and APRIL, HVEM interacts with LIGHT, LT-α and BTLA, LTβR interacts with LT-α1β2 and LIGHT, and OPG interact with RANKL and TRAIL. Yet ligands for RELT, TRAMP, TROY and DR6 have not been identified. Almost all ligands for TNFR superfamily members belong to TNF superfamily (TNFSF). The exceptions are HVEM and EGFR as BTLA and NGF/BDNF/neurotropins are structurally unrelated to TNFSF proteins. The increasingly revealed details of the molecular interaction and signaling pathways have made many TNFRSF members targets of vigorous investigations for disease intervention.

Our TNFRSF-Fc fusion proteins are homodimers linked by a pair of disulfide bonds at the hinge region of mouse IgG2a, affinity purified and size-excluded to homogeneity.