LTβR (Fc-Fusion)

The receptor for lymphotoxin (LTα1β2) was identified in trying to reconcile the difference in binding of TNFR1-Fc and anti-LTα3 antibody. The identified receptor, initially called TNFRRP, contains the cysteine-rich extracellular domain (CRD) and an intracellular domain lacking the death domain.

Interacting protein(s): LT-α1β2, LIGHT
Related products: TNF-Receptor Superfamily

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Quick Specs

Description

The receptor for lymphotoxin (LTα1β2) was identified in trying to reconcile the difference in binding of TNFR1-Fc and anti-LTα3 antibody. The identified receptor, initially called TNFRRP, contains the cysteine-rich extracellular domain (CRD) and an intracellular domain lacking the death domain. The first half of the CD carries sub-domain modules similar to that of the TNFR1 and the second half, that of the TNFR2.

The heterotrimeric form of lymphotoxin is primarily made of one alpha and two beta subunits (LTα1β2) and is the only ligand binds to LTβR. Interestingly, while the beta subunit is structurally very similar to that of the alpha subunit, it surface expression requires the co-expression of the alpha subunit. The observation that the LTβ-deficient, the LTβR-deficient and the LTα-deficient mice suffer lymphoid organ deficiency firmly establishes the LTα1β2-LTβR axis is critical for lympho-organogenesis in periphery.

Importantly, LTβ appears to be a common driver for chronic inflammation, such as Crohn’s disease, thyroiditis, as well as a positive feedback loop stimulate cancer growth by stromal cells, the therapeutic implication of LTβR blockade has been rigorously investigated.

Amino Acid Sequence.

References

1. Crowe PD, VanArsdale TL, Walter BN, Ware CF, Hession C, Ehrenfels B, Browning JL, Din WS, Goodwin RG, Smith CA. (1994) A lymphotoxin-beta-specific receptor. Science. 264:707-710.
2. Browning JL, Ngam-ek A, Lawton P, DeMarinis J, Tizard R, Chow EP, et al. (1993) Lymphotoxin beta, a novel member of the TNF family that forms a heteromeric complex with lymphotoxin on the cell surface. Cell 72:847-856.
3. Rennert PD, Browning JL, Mebius R, Mackay F, Hochman PS. (1996) Surface lymphotoxin alpha/beta complex is required for the development of peripheral lymphoid organs. J Exp Med. 184:1999-2006.