DcR3 (Fc-Fusion)

DcR3, also known as TR6, and M68, is a member of the TNFRSF. DcR3 consists of 300 amino acids lacking a transmembrane domain of TNFRSF and be released as secreted protein.

Interacting protein(s): TL1A-S (P7028F), TL1A-L (P7042F), FASL
Related products: TNF-Receptor Superfamily

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Quick Specs

Description

DcR3, also known as TR6, and M68, is a member of the TNFRSF. DcR3 consists of 300 amino acids lacking a transmembrane domain of TNFRSF and be released as secreted protein.

DcR3 functions as a decoy receptor for TL1A, FasL and LIGHT and inhibits these ligands mediated apoptosis and lymphokine secretion. DcR3 is induced in human antigen-presenting cells such as monocytes and myeloid dendritic cells and intestinal epithelial cells lines by lipopolysaccharide or lipoteichoic acid and is also induced in human dermal microvascular endothelial cells by TNF-α and IL-1β. DcR3 modulates the differentiation and maturation of monocyte, macrophage, and dendritic cells, polarization of naïve T cells into Th-2 immune response, and the negative regulation for activation of B cells by TLR ligands. DcR3 is rarely detectable in serum of healthy subjects, whereas its expression is increased in that of various autoimmune and inflammatory diseases such as IBD, SLE, RA, PBC, silicosis, viral infections, renal failure, and atopic dermatitis as well as cancer.

Interestingly, while DcR3 is shown to protect the development of autoimmune diabetes, IgA nephropathy, and crescent glomerulonephritis in mouse model, the transgene expression of DcR3 leads to SLE like syndrome.

Amino Acid Sequence.

References

1. Pitti RM, Marsters SA, Lawrence DA, Roy M, Kischkel FC, et al. (1998) Genomic amplification of a decoy receptor for Fas ligand in lung and colon cancer. Nature. 396:699-703.
2. Han B, Moore PA, Wu J, Luo H (2007) Overexpression of human decoy receptor 3 in mice results in a systemic lupus erythematosus-like syndrome. Arthritis Rheum. 56:3748-3758.
3. Funke B, Autschbach F, Kim S, Lasitschka F, Strauch U, et al. (2009) Functional characterisation of decoy receptor 3 in Crohn's disease. Gut. 58:483-91.
4. Wang YL, Chou FC, Sung HH, Fan PL, Hsueh CW, et al. (2010) Decoy receptor 3 protects non-obese diabetic mice from autoimmune diabetes by regulating dendritic cell maturation and function. Mol Immunol. 47:2552-2562.