Welcome to AB Biosciences
Cart 0
HVEM (Fc-Fusion)

HVEM (Fc-Fusion)

$ 415.00

HVEM, a member of the TNF receptor family, contains two perfect and two imperfect TNFR-like cysteine-rich domains (CRDs) and a short cytoplasmic tail with some similarity to 4-1BB and CD40.

Interacting protein(s): LT-a (P7006M), LIGHT, BTLA
Related products: TNF-Receptor Superfamily

Read all details below including Quick Specs.

** Please note: For orders over 1 mg, please inquire here

Quick Specs

Species: Human
Catalog no.: P7076F
Synonym: TNFRSF14, ATAR, HVE, LIGHTR, TR2
Tag: mouse IgG2a-Fc
GenBank accession: NM_003820
SwissPro accession: Q92956
Construction: h.HVEM (A38-A140)-m.IgG-Fc
Expression host: 293T
MW (calculated): 38,080 daltons
MW (SDS-PAGE): 41 Kd
Abs 0.1% (= 1 mg/ml): 1.005
Purity: 95 %

Description

HVEM, a member of the TNF receptor family, contains two perfect and two imperfect TNFR-like cysteine-rich domains (CRDs) and a short cytoplasmic tail with some similarity to 4-1BB and CD40. HVEM was initially identified as the cell surface molecule mediating the entry of herpesvisu (HSV) into T lymphocytes. HVEM interacts with three proteins, LIGHT, LT-α (lymphotoxin-α), and BTLA (B and T lymphocyte attenuator).

Importantly, in contrast to LIGHT and LT-α (both are members of TNF ligand superfamily), BTLA belongs to Ig superfamily and is structurally related to the CD28 protein family. Hence, the connection between BTLA and HVEM was not expected. HVEM was described as a co-stimulator triggered by LIGHT and LT-α. However, studies of HVEM-deficient mice and interaction between BTLA and HVEM revealed that HVEM also plays a co-inhibitory role.

In addition to binding BTLA, LIGHT and LT-α, HVEM also interacts with the herpes simplex virus I glycoprotein D (gD) which facilitates virus entry. HVEM mutations have been associated to cases of diffuse large B-cell lymphoma.

Amino Acid Sequence.

References

1. Herpes simplex virus-1 entry into cells mediated by a novel member of the TNF/NGF receptor family. Montgomery R.I., Warner M.S., Lum B.J., Spear P.G. Cell 87:427-436 (1996)

2. A newly identified member of the tumor necrosis factor receptor superfamily with a wide tissue distribution and involvement in lymphocyte activation. Kwon B.S., Tan K.B., Ni J., Oh K.-O., Lee Z.H., Kim K.K., Kim Y.-J., Wang S., Gentz R., Yu G.-L., Harrop J., Lyn S.D., Silverman C., Porter T.G., Truneh A., Young P.R. J. Biol. Chem. 272:14272-14276 (1997)

3. Herpes simplex virus glycoprotein D can bind to poliovirus receptor-related protein 1 or herpesvirus entry mediator, two structurally unrelated mediators of virus entry. Krummenacher C., Nicola A.V., Whitbeck J.C., Lou H., Hou W., Lambris J.D., Geraghty R.J., Spear P.G., Cohen G.H., Eisenberg R.J. J. Virol. 72:7064-7074 (1998)

4. Attenuating lymphocyte activity: the crystal structure of the BTLA-HVEM complex. Compaan D.M., Gonzalez L.C., Tom I., Loyet K.M., Eaton D., Hymowitz S.G. J. Biol. Chem. 280:39553-3956 (2005)


Share this Product


More from this collection