CD27L, also known as CD70, a type II membrane protein, a member of the TNF superfamily and is expressed primarily on activated T-and B-lymphocytes and mature dendritic cells.
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|Synonym:||CD70, CD27LG, TNFSF7|
|Tag:||Mouse IgG2a Fc|
|Construction:||Mouse IgG2a Fc-Human CD27L (S52-P193)|
|MW (calculated):||42,289 daltons|
|MW (SDS-PAGE):||45 Kd|
|Abs 0.1% (= 1 mg/ml):||1.242|
CD27L, also known as CD70, a type II membrane protein, a member of the TNF superfamily and is expressed primarily on activated T-and B-lymphocytes and mature dendritic cells. The interaction of CD70 with CD27 serves as an antigen-dependent and CD80/CD86-independent co-stimulatory signal for an adequate expansion, survival and maintenance of cytotoxic T cells (CTL). CD70 expression is physiologically highly restricted to ensure the transient presence of this protein on the surface of antigen-presenting cells.
This is in consistence with the observation of the escape of BCP-ALL (B cell precursor acute lymphoblastic leukaemia) and CLL (chronic lymphocytic leukaemia) cells, which exhibit low expression levels of CD70, from the immune surveillance. In addition, the identification of the CD27/CD70 pathway in the course of inflammatory diseases, as in EAE, arthritis, and inflammatory bowel disease models, suggests that CD70 may be a target for immune intervention.
Furthermore, the potency of co-stimulation through CD27 suggests that the CD27/CD70 axis can be exploited for the design of anti-cancer vaccines. Lastly, it should be mentioned that in addition to its role in the generation of CTL, CD70 is suggested to play a role in clonal B cell expansion due its transient presence on germinal center lymphocytes.
Amino Acid Sequence
1. Goodwin R.G., Alderson M.R., Smith C.A., Armitage R.J., Vandenbos Tet al. (1993) Molecular and biological characterization of a ligand for CD27 defines a new family of cytokines with homology to tumor necrosis factor. Cell 73:447-456
2. Bowman M.R., Crimmins M.A., Yetz-Aldape J., Kriz R., Kelleher K., Herrmann S. (1994) The cloning of CD70 and its identification as the ligand for CD27. J. Immunol. 152:1756-1761
3. Denoeud J, Moser M. (2011) Role of CD27/CD70 pathway of activation in immunity and tolerance. J Leukoc Biol. 89:195-203