NGFR (Fc-Fusion)

NGFR (nerve growth factor receptor)is also known as p75(NTR) due to its molecular mass and its ability to bind at low affinity with not only NGF, but also other neurotrophins, including brain-derived neurotrophic factor (BDNF), neurotrophin-3 (NTF3), and neurotrophin-4 (NTF4).

Interacting protein(s): NGF, NTF-3, NTF-4, BDNF
Related products: TNF-Receptor Superfamily

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Quick Specs

Description

NGFR (nerve growth factor receptor)is also known as p75(NTR) due to its molecular mass and its ability to bind at low affinity with not only NGF, but also other neurotrophins, including brain-derived neurotrophic factor (BDNF), neurotrophin-3 (NTF3), and neurotrophin-4 (NTF4). NGFR is a member of the TNF receptor superfamily (TNFRSF). Similar to other members of the family, NGFR’s extracellular domain contains the cysteine-rich repeats and it signals through association or dissociation with the intracelluar interactors.

The understanding of NGFR as a TNFRSF member helps to elucidate some of its biological functions including the engagement of NFκB and the apoptosis pathways. As a monomer, NGFR binds NGF with low affinity. Higher affinity binding is achieved by association with other neurotrophin receptors, namely the tropomyosin receptor kinases, TRKA (NTRK1), TRKB (NTRK2), and TRKC (NTRK3). TRKA, TRKB, and TRKC are specific for or 'preferred by' NGF, NTF4 and BDNF, and NTF3, respectively.

NTF3 also binds to TRKA and TRKB, but with significantly lower affinity. The NGFR(-/-) mice were viable and fertile but development skin defects in all extremities and ulcers. In addition, in p75(NTR) deficient mice, a significant reduction in retinal apoptosis compared with the wild-type mice after light exposure was observed. Blockade of NFGR by antiserum or the soluble decoy receptor led to survival of photo-receptors suggesting NGFR can be a therapeutic target.

Amino Acid Sequence

References

1. Bruno F, Abondio P, Montesanto A, Luiselli D, Bruni AC, Maletta R. The Nerve Growth Factor Receptor (NGFR/p75(NTR)): A Major Player in Alzheimer's Disease. Int J Mol Sci. 2023;24(4). Epub 20230206. doi: 10.3390/ijms24043200. PubMed PMID: 36834612; PubMed Central PMCID: PMC9965628.

2. Johnson, D., Lanahan, A., Buck, C. R., Sehgal, A., Morgan, C., Mercer, E., Bothwell, M., Chao, M. (1986) Expression and structure of the human NGF receptor. Cell 47: 545-554.

3. Lee, K. F., Li, E., Huber, J., Landis, S. C., Sharpe, A. H., Chao, M. V., Jaenisch, R. (1992) Targeted mutation of the gene encoding the low affinity NGF receptor p75 leads to deficits in the peripheral sensory nervous system. Cell 69: 737-749

4. Harada, T., Harada, C., Nakayama, N., Okuyama, S., Yoshida, K., Kohsaka, S., Matsuda, H., Wada, K. (2000) Modification of glial-neuronal cell interactions prevents photoreceptor apoptosis during light-induced retinal degeneration. Neuron 26: 533-541.

5. Underwood CK, Coulson EJ (2008) The p75 neurotrophin receptor. Int J Biochem Cell Biol 40:1664–1668