TL1A, a type II membrane protein and a member of the TNF superfamily, is also known as vascular endothelial growth inhibitor (VEGI)-251. Although TL1A was identified as a longer variant of TL1/VEGI, it has been presumed that the original TL1/VEGI was a cloning artifact.
Interacting protein(s): DR3 (P7065F), DcR3 (P7073F)
Related products: Hexa-Ligand
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Quick Spec
| Species: | Human |
| Catalog No.: | P7042F |
| Synonym: | TNFSF15, MGC129934, MGC129935, TL1, TL1A, VEGI, VEGI192A |
| Tag: | Mouse IgG2a Fc |
| GenBank Accession: | NM_005118 |
| SwissPro Accession: | O95150 |
| Expression Host: | 293T |
| Construction: | Mouse IgG2a Fc-Human TL1A (L72-L251) |
| MW (calculated): | 47,137 daltons |
| MW (SDS-PAGE): | 50 Kd |
| Abs 0.1% (= 1 mg/ml): | 1.153 |
| Purity: | 95% |
Description
TL1A, a type II membrane protein and a member of the TNF superfamily, is also known as vascular endothelial growth inhibitor (VEGI)-251. Although TL1A was identified as a longer variant of TL1/VEGI, it has been presumed that the original TL1/VEGI was a cloning artifact. TL1A is initially expressed as a membrane-bound protein and is subsequently released as a soluble protein via ectodomain shedding by a metalloproteinase such as TNF-α converting enzyme (TACE).
TL1A is constitutively expressed by endothelial cells, such as the human umbilical vein endothelial cells, synovial fibroblast-like cells, the vascular endothelial cells in the kidney and prostate and can be up-regulated by stimulation with TNF-α, IL-1, and PMA. In addition, TL1A can be transiently induced in macrophage and dendritic cells upon activation by Toll-like receptor (TLR) ligands, enteric bacteria, and Fcγ receptor (FcγR) crosslinking. TL1A binds to two receptors, DR3 and DcR3.
TL1A-DR3 interaction forms a part of the inflammatory cytokine network and contribute to rheumatoid arthritis (RA) and intestinal bowl disease (IBS). The DcR3 functions as a decoy receptor for TL1A as well as FasL and LIGHT.
Amino Acid Sequence
References
1. Xu WD, Li R, Huang AF. Role of TL1A in Inflammatory Autoimmune Diseases: A Comprehensive Review. Front Immunol. 2022;13:891328. Epub 20220714. doi: 10.3389/fimmu.2022.891328. PubMed PMID: 35911746; PubMed Central PMCID: PMC9329929.
2. Migone TS, Zhang J, Luo X, Zhuang L, Chen C, et al, (2002) TL1A is a TNF-like ligand for DR3 and TR6/DcR3 and functions as a T cell costimulator. Immunity 16(3):479-492.
3. Zhang J, Salcedo TW, Wan X, Ullrich S, Hu B, Gregorio T, et al. (2001) Modulation of T-cell responses to alloantigens by TR6/DcR3. J Clin Invest 107:1459-1468.
4. Meylan F, Song YJ, Fuss I, Villarreal S, Kahle E, Malm IJ, et al. (2011) The TNF-family cytokine TL1A drives IL-13-dependent small intestinal inflammation. Mucosal Immunol. 4:172-185.
5. Bull MJ, Williams AS, Mecklenburgh Z, Calder CJ, Twohig JP, et al. (2008) The Death Receptor 3-TNF-like protein 1A pathway drives adverse bone pathology in inflammatory arthritis. J Exp Med. 205:2457-2464.